Copper-Catalyzed Syntheses of Pyrene-Pyrazole Pharmacophores and Structure Activity Studies for Tubulin Polymerization

[Image: see text] Tubulin polymerization is critical in mitosis process, which regulates uncontrolled cell divisions. Here, we report a new class of pyrene-pyrazole pharmacophore (PPP) for targeting microtubules. Syntheses of seven pyrenyl-substituted pyrazoles with side-chain modification at N-1 an...

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Détails bibliographiques
Publié dans:ACS Omega
Auteurs principaux: Sar, Dinabandhu, Srivastava, Indrajit, Misra, Santosh K., Ostadhossein, Fatemeh, Fathi, Parinaz, Pan, Dipanjan
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2018
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130796/
https://ncbi.nlm.nih.gov/pubmed/30221233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00320
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