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Copper-Catalyzed Syntheses of Pyrene-Pyrazole Pharmacophores and Structure Activity Studies for Tubulin Polymerization
[Image: see text] Tubulin polymerization is critical in mitosis process, which regulates uncontrolled cell divisions. Here, we report a new class of pyrene-pyrazole pharmacophore (PPP) for targeting microtubules. Syntheses of seven pyrenyl-substituted pyrazoles with side-chain modification at N-1 an...
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| 發表在: | ACS Omega |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American
Chemical
Society
2018
|
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6130796/ https://ncbi.nlm.nih.gov/pubmed/30221233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.8b00320 |
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