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Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach

Context: Alzheimer’s disease (AD) is the most common form of dementia affecting the aged population and neuroinflammation is one of the most observed AD pathologies. NF-κB is the central regulator of inflammation and inhibitor κB kinase (IKK) is the converging point in NF-κB activation. Celastrol is...

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Detalhes bibliográficos
Publicado no:Pharm Biol
Main Authors: Veerappan, Karpagam, Natarajan, Sathishkumar, Ethiraj, Purushoth, Vetrivel, Umashankar, Samuel, Shila
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130723/
https://ncbi.nlm.nih.gov/pubmed/27931154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13880209.2016.1241809
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