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On the importance of accounting for nuclear quantum effects in ab initio calibrated force fields in biological simulations

In many important processes in chemistry, physics, and biology the nuclear degrees of freedom cannot be described using the laws of classical mechanics. At the same time, the vast majority of molecular simulations that employ wide-coverage force fields treat atomic motion classically. In light of th...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Pereyaslavets, Leonid, Kurnikov, Igor, Kamath, Ganesh, Butin, Oleg, Illarionov, Alexey, Leontyev, Igor, Olevanov, Michael, Levitt, Michael, Kornberg, Roger D., Fain, Boris
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130346/
https://ncbi.nlm.nih.gov/pubmed/30127031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806064115
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