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Discovering epistatic feature interactions from neural network models of regulatory DNA sequences

MOTIVATION: Transcription factors bind regulatory DNA sequences in a combinatorial manner to modulate gene expression. Deep neural networks (DNNs) can learn the cis-regulatory grammars encoded in regulatory DNA sequences associated with transcription factor binding and chromatin accessibility. Sever...

詳細記述

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書誌詳細
出版年:Bioinformatics
主要な著者: Greenside, Peyton, Shimko, Tyler, Fordyce, Polly, Kundaje, Anshul
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129272/
https://ncbi.nlm.nih.gov/pubmed/30423062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty575
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