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Potentiation of PD-L1 blockade with a potency-matched dual cytokine–antibody fusion protein leads to cancer eradication in BALB/c-derived tumors but not in other mouse strains
We have recently described a novel therapeutic antibody product (IL2–F8–TNF(mut)), featuring the simultaneous fusion of murine IL2 and of a TNF mutant with scFv(F8), an antibody specific to the alternatively-spliced extra domain A of fibronectin (EDA). Here, we report on the in vivo characterization...
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| Publicado no: | Cancer Immunol Immunother |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6129175/ https://ncbi.nlm.nih.gov/pubmed/29971465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-018-2194-0 |
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