Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Protein interacting with C kinase (PICK1) is a scaffolding protein that is present in dendritic spines and interacts with a wide array of proteins through its PDZ domain. The best understood function of PICK1 is regulation of trafficking of AMPA receptors at neuronal synapses via its specific intera...

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Publicat a:Sci Rep
Autors principals: Lin, Edward Y. S., Silvian, Laura F., Marcotte, Douglas J., Banos, Charles C., Jow, Flora, Chan, Timothy R., Arduini, Robert M., Qian, Fang, Baker, Darren P., Bergeron, Chris, Hession, Catherine A., Huganir, Richard L., Borenstein, Cassandra F., Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J., Scannevin, Robert H., Dunah, Anthone W., Guckian, Kevin M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128908/
https://ncbi.nlm.nih.gov/pubmed/30194389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31680-3
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