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Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells

Haploinsufficiency and aneuploidy are two phenomena, where gene dosage alterations cause severe defects ultimately resulting in developmental failures and disease. One remarkable exception is the X chromosome, where copy number differences between sexes are buffered by dosage compensation systems. I...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Valsecchi, Claudia Isabelle Keller, Basilicata, M. Felicia, Semplicio, Giuseppe, Georgiev, Plamen, Gutierrez, Noel Marie, Akhtar, Asifa
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128902/
https://ncbi.nlm.nih.gov/pubmed/30194291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05642-2
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