Aging aggravates hepatic ischemia-reperfusion injury in mice by impairing mitophagy with the involvement of the EIF2α-parkin pathway

Hepatic ischemia-reperfusion (I/R) injury fundamentally influences the performance of aged liver grafts. The significance of mitophagy in the age dependence of sensitivity to I/R injury remains poorly understood. Here, we show that aging aggravated hepatic I/R injury with decreased mitophagy in mice...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Li, Yang, Ruan, Dan-yun, Jia, Chang-chang, Zheng, Jun, Wang, Guo-ying, Zhao, Hui, Yang, Qing, Liu, Wei, Yi, Shu-hong, Li, Hua, Wang, Gen-shu, Yang, Yang, Chen, Gui-hua, Zhang, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128434/
https://ncbi.nlm.nih.gov/pubmed/30089704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101511
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