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Clinical significance of PD-L1(+) exosomes in plasma of Head and Neck Cancer patients

PURPOSE: The microenvironment of head and neck squamous cell carcinomas (HNSCCs) is highly immunosuppressive. HNSCCs expressing elevated levels of PD-L1 have especially poor outcome. Exosomes that carry PD-L1 and suppress T-cell functions have been isolated from plasma of patients with HNSCC. The po...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Theodoraki, Marie-Nicole, Yerneni, Saigopalakrishna S., Hoffmann, Thomas K., Gooding, William E., Whiteside, Theresa L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126905/
https://ncbi.nlm.nih.gov/pubmed/29233903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2664
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