Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice

OBJECTIVES: Spinal muscular atrophy (SMA) is a devastating motor neuron disorder caused by homozygous loss of the survival motor neuron 1 (SMN1) gene and insufficient functional SMN protein produced by the SMN2 copy gene. Additional genetic protective modifiers such as Plastin 3 (PLS3) can counterac...

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發表在:PLoS One
Main Authors: Strathmann, Eike A., Peters, Miriam, Hosseinibarkooie, Seyyedmohsen, Rigo, Frank W., Bennett, C. Frank, Zaworski, Phillip G., Chen, Karen S., Nothnagel, Michael, Wirth, Brunhilde
格式: Artigo
語言:Inglês
出版: Public Library of Science 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126849/
https://ncbi.nlm.nih.gov/pubmed/30188931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203398
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