Enhanced Therapeutic Activity of Non-Internalizing Small Molecule-Drug Conjugates Targeting Carbonic Anhydrase IX in Combination With Targeted Interleukin-2

PURPOSE: Antibody-drug conjugates and small molecule-drug conjugates have been proposed as alternatives to conventional anti-cancer cytotoxic agents, with the potential to deliver bioactive payloads to the site of disease, helping spare normal tissues. EXPERIMENTAL DESIGN: Here we describe a novel s...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Cazzamalli, Samuele, Ziffels, Barbara, Widmayer, Fontaine, Murer, Patrizia, Pellegrini, Giovanni, Pretto, Francesca, Wulhfard, Sarah, Neri, Dario
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126628/
https://ncbi.nlm.nih.gov/pubmed/29691298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3457
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