Fasudil inhibits actin polymerization and collagen synthesis and induces apoptosis in human urethral scar fibroblasts via the Rho/ROCK pathway

PURPOSE: To examine the effects and mechanism of action of fasudil on cytoskeletal polymerization, collagen synthesis, and apoptosis in fibroblasts derived from human urethral scar tissue. MATERIALS AND METHODS: Fibroblasts treated with or without transforming growth factor β1 (TGF-β1, 10 ng/mL) wer...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Li, Xiao-Dong, Wu, Yu-Peng, Chen, Shao-Hao, Liang, Ying-Chun, Lin, Ting-Ting, Lin, Tian, Wei, Yong, Xue, Xue-Yi, Zheng, Qing-Shui, Xu, Ning
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126504/
https://ncbi.nlm.nih.gov/pubmed/30214158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S156095
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