S1PR3 Mediates Itch and Pain via Distinct TRP Channel-Dependent Pathways

Sphingosine 1-phosphate (S1P) is a bioactive signaling lipid associated with a variety of chronic pain and itch disorders. S1P signaling has been linked to cutaneous pain, but its role in itch has not yet been studied. Here, we find that S1P triggers itch and pain in male mice in a concentration-dep...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Hill, Rose Z., Morita, Takeshi, Brem, Rachel B., Bautista, Diana M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125817/
https://ncbi.nlm.nih.gov/pubmed/30082422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1266-18.2018
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