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New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir

Letermovir is a human cytomegalovirus (CMV) terminase inhibitor recently approved as prophylaxis in stem cell transplant recipients. In further studies of emerging drug resistance, a baseline laboratory CMV strain was serially propagated in cell culture under a combination of letermovir and ganciclo...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chou, Sunwen, Satterwhite, L. Elizabeth, Ercolani, Ronald J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125535/
https://ncbi.nlm.nih.gov/pubmed/29914965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00922-18
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