Effects of tumor treating fields (TTFields) on glioblastoma cells are augmented by mitotic checkpoint inhibition

Tumor treating fields (TTFields) are approved for glioblastoma (GBM) therapy. TTFields disrupt cell division by inhibiting spindle fiber formation. Spindle assembly checkpoint (SAC) inhibition combined with antimitotic drugs synergistically decreases glioma cell growth in cell culture and mice. We h...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Death Discov
Main Authors: Kessler, Almuth F., Frömbling, Greta E., Gross, Franziska, Hahn, Mirja, Dzokou, Wilfrid, Ernestus, Ralf-Ingo, Löhr, Mario, Hagemann, Carsten
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125382/
https://ncbi.nlm.nih.gov/pubmed/30210815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0079-9
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