SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death

The molecular mechanisms underlying the severe lung pathology that occurs during SARS-CoV infections remain incompletely understood. The largest of the SARS-CoV accessory protein open reading frames (SARS 3a) oligomerizes, dynamically inserting into late endosomal, lysosomal, and trans-Golgi-network...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Yue, Yuan, Nabar, Neel R., Shi, Chong-Shan, Kamenyeva, Olena, Xiao, Xun, Hwang, Il-Young, Wang, Min, Kehrl, John H.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125346/
https://ncbi.nlm.nih.gov/pubmed/30185776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0917-y
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