Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitulates the mutational spectrum and transcriptio...

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Veröffentlicht in:Cancer Discov
Hauptverfasser: Tiriac, Hervé, Belleau, Pascal, Engle, Dannielle D., Plenker, Dennis, Deschênes, Astrid, Somerville, Tim D. D., Froeling, Fieke E. M., Burkhart, Richard A., Denroche, Robert E., Jang, Gun-Ho, Miyabayashi, Koji, Young, C. Megan, Patel, Hardik, Ma, Michelle, LaComb, Joseph F., Palmaira, Randze Lerie D., Javed, Ammar A., Huynh, Jasmine C., Johnson, Molly, Arora, Kanika, Robine, Nicolas, Shah, Minita, Sanghvi, Rashesh, Goetz, Austin B., Lowder, Cinthya Y., Martello, Laura, Driehuis, Else, LeComte, Nicolas, Askan, Gokce, Iacobuzio-Donahue, Christine A., Clevers, Hans, Wood, Laura D., Hruban, Ralph H., Thompson, Elizabeth, Aguirre, Andrew J., Wolpin, Brian M., Sasson, Aaron, Kim, Joseph, Wu, Maoxin, Bucobo, Juan Carlos, Allen, Peter, Sejpal, Divyesh V., Nealon, William, Sullivan, James D., Winter, Jordan M., Gimotty, Phyllis A., Grem, Jean L., DiMaio, Dominick J., Buscaglia, Jonathan M., Grandgenett, Paul M., Brody, Jonathan R., Hollingsworth, Michael A., O’Kane, Grainne M., Notta, Faiyaz, Kim, Edward, Crawford, James M., Devoe, Craig, Ocean, Allyson, Wolfgang, Christopher L., Yu, Kenneth H., Li, Ellen, Vakoc, Christopher R., Hubert, Benjamin, Fischer, Sandra E., Wilson, Julie M., Moffitt, Richard, Knox, Jennifer, Krasnitz, Alexander, Gallinger, Steven, Tuveson, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125219/
https://ncbi.nlm.nih.gov/pubmed/29853643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0349
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