Etomoxir inhibits macrophage polarization by disrupting CoA homeostasis

Long chain fatty acid (LCFA) oxidation has been shown to play an important role in IL-4-mediated macrophage polarization [M(IL-4)]. However, many of these conclusions are based on the inhibition of carnitine palmitoyltransferase-1 with high concentrations of etomoxir that far exceed what is required...

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Bibliografski detalji
Izdano u:Cell Metab
Glavni autori: Divakaruni, Ajit S., Hsieh, Wei Yuan, Minarrieta, Lucía, Duong, Tin N., Kim, Kristen K.O., Desousa, Brandon R., Andreyev, Alexsander Y., Bowman, Caitlyn E., Caradonna, Kacey, Dranka, Brian P., Ferrick, David A., Liesa, Marc, Stiles, Linsey, Rogers, George W., Braas, Daniel, Ciaraldi, Theodore P., Wolfgang, Michael J., Sparwasser, Tim, Berod, Luciana, Bensinger, Steven J., Murphy, Anne N.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125190/
https://ncbi.nlm.nih.gov/pubmed/30043752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.06.001
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