Characterization of new, efficient Mycobacterium tuberculosis topoisomerase-I inhibitors and their interaction with human ABC multidrug transporters

Drug resistant tuberculosis (TB) is a major worldwide health problem. In addition to the bacterial mechanisms, human drug transporters limiting the cellular accumulation and the pharmacological disposition of drugs also influence the efficacy of treatment. Mycobacterium tuberculosis topoisomerase-I...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Temesszentandrási-Ambrus, Csilla, Tóth, Szilárd, Verma, Rinkee, Bánhegyi, Péter, Szabadkai, István, Baska, Ferenc, Szántai-Kis, Csaba, Hartkoorn, Ruben C., Lingerfelt, Mary A., Sarkadi, Balázs, Szakács, Gergely, Őrfi, László, Nagaraja, Valakunja, Ekins, Sean, Telbisz, Ágnes
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124754/
https://ncbi.nlm.nih.gov/pubmed/30183750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202749
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