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Helicase-dependent RNA decay illuminated by a cryo-EM structure of a human nuclear RNA exosome-MTR4 complex
The ribonucleolytic RNA exosome interacts with RNA helicases to degrade RNA. To understand how the 3′ to 5′ Mtr4 helicase engages RNA and the nuclear exosome, we reconstituted fourteen-subunit Mtr4-containing RNA exosomes from Saccharomyces cerevisiae, Schizosaccharomyces pombe and human and show th...
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| Gepubliceerd in: | Cell |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6124691/ https://ncbi.nlm.nih.gov/pubmed/29906447 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.05.041 |
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