Synergistic antiproliferative effects of an mTOR inhibitor (rad001) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity

Although gemcitabine plus cisplatin is the gold standard chemotherapy regimen for advanced cholangiocarcinoma, the response rate has been disappointing. This study aims to investigate a novel therapeutic regimen [gemcitabine plus everolimus (rad001), an mTOR inhibitor] for cholangiocarcinoma. Gemcit...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Dis Model Mech
Main Authors: Lin, Gigin, Lin, Kun-Ju, Wang, Frank, Chen, Tse-Ching, Yen, Tzu-Chen, Yeh, Ta-Sen
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124555/
https://ncbi.nlm.nih.gov/pubmed/29666220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.033050
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