Chikungunya virus impairs draining lymph node function by inhibiting HEV-mediated lymphocyte recruitment

Chikungunya virus (CHIKV) causes acute and chronic rheumatologic disease. Pathogenic CHIKV strains persist in joints of immunocompetent mice, while the attenuated CHIKV strain 181/25 is cleared by adaptive immunity. We analyzed the draining lymph node (dLN) to define events in lymphoid tissue that m...

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Publicat a:JCI Insight
Autors principals: McCarthy, Mary K., Davenport, Bennett J., Reynoso, Glennys V., Lucas, Erin D., May, Nicholas A., Elmore, Susan A., Tamburini, Beth A., Hickman, Heather D., Morrison, Thomas E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124534/
https://ncbi.nlm.nih.gov/pubmed/29997290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121100
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