A mono-carbonyl analog of curcumin induces apoptosis in drug-resistant EGFR-mutant lung cancer through the generation of oxidative stress and mitochondrial dysfunction

INTRODUCTION: Targeted therapies using epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC) patients harboring EGFR mutations, leading to the approval of gefitinib and erlotinib as standard first-line clinical...

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Detalles Bibliográficos
Publicado en:Cancer Manag Res
Main Authors: Dai, Xuanxuan, Zhang, Junru, Guo, Guilong, Cai, Yuepiao, Cui, Ri, Yin, Changtian, Liu, Weidong, Vinothkumar, Rajamanickam, Zhang, Tingting, Liang, Guang, Zhang, Xiaohua
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2018
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124478/
https://ncbi.nlm.nih.gov/pubmed/30214301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S159660
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