Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate

Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly overexpressed on the surface of diverse human carcinomas and is an attractive target for the development of mAb-based therapeutics. However, attempts at targeting the shed MUC1 N-terminal subunit have been unsuccessful. We report here the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Panchamoorthy, Govind, Jin, Caining, Raina, Deepak, Bharti, Ajit, Yamamoto, Masaaki, Adeebge, Dennis, Zhao, Qing, Bronson, Roderick, Jiang, Shirley, Li, Linjing, Suzuki, Yozo, Tagde, Ashujit, Ghoroghchian, P. Peter, Wong, Kwok-Kin, Kharbanda, Surender, Kufe, Donald
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2018
Gaiak:
Technical Advance
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124453/
https://ncbi.nlm.nih.gov/pubmed/29925694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99880
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