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Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin

Cachexia syndrome consists of adipose and muscle loss, often despite normal food intake. We hypothesized that cachexia-associated adipose wasting is driven in part by tumor humoral factors that induce adipocyte lipolysis. We developed an assay to purify secreted factors from a cachexia-inducing colo...

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Publicat a:JCI Insight
Autors principals: Arora, Gurpreet K., Gupta, Arun, Narayanan, Sriram, Guo, Tong, Iyengar, Puneeth, Infante, Rodney E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124433/
https://ncbi.nlm.nih.gov/pubmed/30046014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121221
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