Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase

Pulmonary arterial hypertension (PAH) remains a disease with limited therapeutic options and dismal prognosis. Despite its etiologic heterogeneity, the underlying unifying pathophysiology is characterized by increased vascular tone and adverse remodeling of the pulmonary circulation. Myeloperoxidase...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Klinke, Anna, Berghausen, Eva, Friedrichs, Kai, Molz, Simon, Lau, Denise, Remane, Lisa, Berlin, Matthias, Kaltwasser, Charlotte, Adam, Matti, Mehrkens, Dennis, Mollenhauer, Martin, Manchanda, Kashish, Ravekes, Thorben, Heresi, Gustavo A., Aytekin, Metin, Dweik, Raed A., Hennigs, Jan K., Kubala, Lukas, Michaëlsson, Erik, Rosenkranz, Stephan, Rudolph, Tanja K., Hazen, Stanley L., Klose, Hans, Schermuly, Ralph T., Rudolph, Volker, Baldus, Stephan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124430/
https://ncbi.nlm.nih.gov/pubmed/29875311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97530
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