Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase

Pulmonary arterial hypertension (PAH) remains a disease with limited therapeutic options and dismal prognosis. Despite its etiologic heterogeneity, the underlying unifying pathophysiology is characterized by increased vascular tone and adverse remodeling of the pulmonary circulation. Myeloperoxidase...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Klinke, Anna, Berghausen, Eva, Friedrichs, Kai, Molz, Simon, Lau, Denise, Remane, Lisa, Berlin, Matthias, Kaltwasser, Charlotte, Adam, Matti, Mehrkens, Dennis, Mollenhauer, Martin, Manchanda, Kashish, Ravekes, Thorben, Heresi, Gustavo A., Aytekin, Metin, Dweik, Raed A., Hennigs, Jan K., Kubala, Lukas, Michaëlsson, Erik, Rosenkranz, Stephan, Rudolph, Tanja K., Hazen, Stanley L., Klose, Hans, Schermuly, Ralph T., Rudolph, Volker, Baldus, Stephan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124430/
https://ncbi.nlm.nih.gov/pubmed/29875311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97530
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