Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models

Planar cell polarity (PCP) describes a cell–cell communication process through which individual cells coordinate and align within the plane of a tissue. In this study, we show that overexpression of Fuz, a PCP gene, triggers neuronal apoptosis via the dishevelled/Rac1 GTPase/MEKK1/JNK/caspase signal...

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Publicat a:EMBO Rep
Autors principals: Chen, Zhefan Stephen, Li, Li, Peng, Shaohong, Chen, Francis M, Zhang, Qian, An, Ying, Lin, Xiao, Li, Wen, Koon, Alex Chun, Chan, Ting‐Fung, Lau, Kwok‐Fai, Ngo, Jacky Chi Ki, Wong, Wing Tak, Kwan, Kin Ming, Chan, Ho Yin Edwin
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123661/
https://ncbi.nlm.nih.gov/pubmed/30026307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745409
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