Sirt1 protects from K‐Ras‐driven lung carcinogenesis

The NAD (+)‐dependent deacetylase SIRT1 can be oncogenic or tumor suppressive depending on the tissue. Little is known about the role of SIRT1 in non‐small cell lung carcinoma (NSCLC), one of the deadliest cancers, that is frequently associated with mutated K‐RAS. Therefore, we investigated the effe...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Costa‐Machado, Luis Filipe, Martín‐Hernández, Roberto, Sanchez‐Luengo, Miguel Ángel, Hess, Katharina, Vales‐Villamarin, Claudia, Barradas, Marta, Lynch, Cian, de la Nava, Daniel, Diaz‐Ruiz, Alberto, de Cabo, Rafael, Cañamero, Marta, Martinez, Lola, Sanchez‐Carbayo, Marta, Herranz, Daniel, Serrano, Manuel, Fernandez‐Marcos, Pablo J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123659/
https://ncbi.nlm.nih.gov/pubmed/30021836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643879
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