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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer syndrome

Genetic overexpression of the protein deacetylase Sir2 increases longevity in a variety of lower organisms, and this has prompted a great interest on the effects of its closest mammalian homologue, Sirt1, on aging and cancer. We have generated transgenic mice moderately overexpressing Sirt1 under it...

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Библиографические подробности
Главные авторы: Herranz, Daniel, Cañamero, Marta, Mulero, Francisca, Martinez-Pastor, Barbara, Fernandez-Capetillo, Oscar, Serrano, Manuel
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3641391/
https://ncbi.nlm.nih.gov/pubmed/20975665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1001
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