The Telomerase Complex Directly Controls Hematopoietic Stem Cell Differentiation and Senescence in an Induced Pluripotent Stem Cell Model of Telomeropathy

Telomeropathies are rare disorders associated with impaired telomere length control mechanisms that frequently result from genetic mutations in the telomerase complex. Dyskeratosis congenita is a congenital progressive telomeropathy in which mutation in the telomerase RNA component (TERC) impairs te...

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Dades bibliogràfiques
Publicat a:Front Genet
Autors principals: Jose, Shyam Sushama, Tidu, Federico, Burilova, Petra, Kepak, Tomas, Bendickova, Kamila, Fric, Jan
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123533/
https://ncbi.nlm.nih.gov/pubmed/30210531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00345
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