The Telomerase Complex Directly Controls Hematopoietic Stem Cell Differentiation and Senescence in an Induced Pluripotent Stem Cell Model of Telomeropathy

Telomeropathies are rare disorders associated with impaired telomere length control mechanisms that frequently result from genetic mutations in the telomerase complex. Dyskeratosis congenita is a congenital progressive telomeropathy in which mutation in the telomerase RNA component (TERC) impairs te...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Jose, Shyam Sushama, Tidu, Federico, Burilova, Petra, Kepak, Tomas, Bendickova, Kamila, Fric, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123533/
https://ncbi.nlm.nih.gov/pubmed/30210531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2018.00345
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