Structural basis for the complete resistance of the human prion protein mutant G127V to prion disease

Prion diseases are caused by the propagation of misfolded cellular prion proteins (PrPs). A completely prion disease-resistant genotype, V127M129, has been identified in Papua New Guinea and verified in transgenic mice. To disclose the structural basis of the disease-resistant effect of the G127V mu...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zheng, Zhen, Zhang, Meilan, Wang, Yongheng, Ma, Rongsheng, Guo, Chenyun, Feng, Liubin, Wu, Jihui, Yao, Hongwei, Lin, Donghai
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123418/
https://ncbi.nlm.nih.gov/pubmed/30181558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31394-6
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