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Solution Structure and Dynamics of the I214V Mutant of the Rabbit Prion Protein
BACKGROUND: The conformational conversion of the host-derived cellular prion protein (PrP(C)) into the disease-associated scrapie isoform (PrP(Sc)) is responsible for the pathogenesis of transmissible spongiform encephalopathies (TSEs). Various single-point mutations in PrP(C)s could cause structura...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951349/ https://ncbi.nlm.nih.gov/pubmed/20949107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013273 |
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