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Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia

Hyperhomocysteinemia due to cystathionine beta synthase (CBS) deficiency is associated with diverse cognitive dysfunction. Considering the role of the serine/threonine kinase DYRK1A, not only in developmental defects with life-long structural and functional consequences, but also in multiple neurode...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Baloula, Vanessa, Fructuoso, Marta, Kassis, Nadim, Gueddouri, Dalale, Paul, Jean-Louis, Janel, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122394/
https://ncbi.nlm.nih.gov/pubmed/30172984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.08.015
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