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Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation

Simultaneous activation of bile acid receptors farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) by INT-767 significantly reduces atherosclerotic formation. In this study, we investigated the effect of simultaneous inactivation of these bile acid receptors in atheroscleros...

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Bibliografske podrobnosti
izdano v:J Lipid Res
Main Authors: Miyazaki-Anzai, Shinobu, Masuda, Masashi, Kohno, Shohei, Levi, Moshe, Shiozaki, Yuji, Keenan, Audrey L., Miyazaki, Makoto
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121929/
https://ncbi.nlm.nih.gov/pubmed/29976576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M087239
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