CRISPR/Cas9-mediated Angptl8 knockout suppresses plasma triglyceride concentrations and adiposity in rats

Angiopoietin-like protein (ANGPTL)8 is a liver- and adipocyte-derived protein that controls plasma triglyceride (TG) levels. Most animal studies have used mouse models. Here, we generated an Angptl8 KO rat model using a clustered regulatory interspaced short palindromic repeat (CRISPR)/CRISPR-associ...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Izumi, Ryota, Kusakabe, Toru, Noguchi, Michio, Iwakura, Hiroshi, Tanaka, Tomohiro, Miyazawa, Takashi, Aotani, Daisuke, Hosoda, Kiminori, Kangawa, Kenji, Nakao, Kazuwa
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121927/
https://ncbi.nlm.nih.gov/pubmed/30042156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M082099
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