Leptin Activates Hepatic 5′-AMP-activated Protein Kinase through Sympathetic Nervous System and α1-Adrenergic Receptor: A POTENTIAL MECHANISM FOR IMPROVEMENT OF FATTY LIVER IN LIPODYSTROPHY BY LEPTIN

Leptin is an adipocyte-derived hormone that regulates energy homeostasis. Leptin treatment strikingly ameliorates metabolic disorders of lipodystrophy, which exhibits ectopic fat accumulation and severe insulin-resistant diabetes due to a paucity of adipose tissue. Although leptin is shown to activa...

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Detalhes bibliográficos
Main Authors: Miyamoto, Licht, Ebihara, Ken, Kusakabe, Toru, Aotani, Daisuke, Yamamoto-Kataoka, Sachiko, Sakai, Takeru, Aizawa-Abe, Megumi, Yamamoto, Yuji, Fujikura, Junji, Hayashi, Tatsuya, Hosoda, Kiminori, Nakao, Kazuwa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504759/
https://ncbi.nlm.nih.gov/pubmed/23024365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.384545
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