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Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung
PURPOSE: The current study was designed to address our hypothesis that oxidative stress secondary to the ionizing event upregulates PTEN mRNA and protein in the lungs of C57BL/6J mice through oxidative DNA damage resulting in CpG hypomethylation in the PTEN promoter. METHODS: Fibrosis-prone C57BL/6J...
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| Publicat a: | Free Radic Res |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6121701/ https://ncbi.nlm.nih.gov/pubmed/27367846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10715762.2016.1189078 |
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