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Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung

PURPOSE: The current study was designed to address our hypothesis that oxidative stress secondary to the ionizing event upregulates PTEN mRNA and protein in the lungs of C57BL/6J mice through oxidative DNA damage resulting in CpG hypomethylation in the PTEN promoter. METHODS: Fibrosis-prone C57BL/6J...

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Detalhes bibliográficos
Publicado no:Free Radic Res
Main Authors: Zhang, Xiuwu, Hadley, Caroline, Jackson, Isabel L., Zhang, Yi, Zhang, Angel, Spasojevic, Ivan, Haberle, Ines Batinic, Vujaskovic, Zeljko
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121701/
https://ncbi.nlm.nih.gov/pubmed/27367846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10715762.2016.1189078
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