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The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression

Hypoxia-inducible factors (HIFs) are key regulators of hypoxic responses, and their stability and transcriptional activity are controlled by several kinases. However, the regulation of HIF by protein phosphatases has not been thoroughly investigated. Here, we found that overexpression of Mg(2+)/Mn(2...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Pyo, Jaehyuk, Ryu, Jaewook, Kim, Wootae, Choi, Jae-Sun, Jeong, Joo-Won, Kim, Ja-Eun
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6121667/
https://ncbi.nlm.nih.gov/pubmed/30081604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19082297
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