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Machine learning identifies interacting genetic variants contributing to breast cancer risk: A case study in Finnish cases and controls

We propose an effective machine learning approach to identify group of interacting single nucleotide polymorphisms (SNPs), which contribute most to the breast cancer (BC) risk by assuming dependencies among BCAC iCOGS SNPs. We adopt a gradient tree boosting method followed by an adaptive iterative S...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Behravan, Hamid, Hartikainen, Jaana M., Tengström, Maria, Pylkäs, Katri, Winqvist, Robert, Kosma, Veli–Matti, Mannermaa, Arto
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120908/
https://ncbi.nlm.nih.gov/pubmed/30177847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31573-5
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