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High mutation burden of circulating cell‐free DNA in early‐stage breast cancer patients is associated with a poor relapse‐free survival

BACKGROUND: High tumor mutation burden is shown to be associated with a poor clinical outcome. As the tumor‐derived fraction of circulating cell‐free DNA (cfDNA) is shown to reflect the genetic spectrum of the tumor, we examined whether the mutation burden of cfDNA could be used to predict the clini...

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Bibliografski detalji
Izdano u:Cancer Med
Glavni autori: Kujala, Jouni, Hartikainen, Jaana M., Tengström, Maria, Sironen, Reijo, Kosma, Veli‐Matti, Mannermaa, Arto
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433819/
https://ncbi.nlm.nih.gov/pubmed/32602248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3258
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