Activation of hepatic stem cells compartment during hepatocarcinogenesis in a HBsAg HBV-transgenic mouse model

Chronic infection of Hepatitis B Virus (HBV) is one of the highest risk factors of hepatocellular carcinoma (HCC). The accumulation of HBV surface antigen (HBsAg) into hepatocytes induces inflammation and oxidative stress, impairing their replicative ability and allowing the activation of the hepati...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Anfuso, Beatrice, El-Khobar, Korri E., Ie, Susan I., Avellini, Claudio, Radillo, Oriano, Raseni, Alan, Tiribelli, Claudio, Sukowati, Caecilia H. C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120871/
https://ncbi.nlm.nih.gov/pubmed/30177788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31406-5
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