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N(4)-Tetradentate chelators efficiently regulate copper homeostasis and prevent ROS production induced by copper-amyloid-β(1-16), even in the presence of an excess of zinc
The disruption of copper homeostasis and the oxidative stress induced by Cu-amyloids are crucial features of Alzheimer’s disease pathology. The copper specific N(4)-tetradendate ligands TDMQ20 and 1 are able to fully inhibit in vitro the aerobic oxidation of ascorbate induced by Cu-Aβ(1-16), even in...
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| Publicat a: | Chemistry |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6120676/ https://ncbi.nlm.nih.gov/pubmed/29687932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201801387 |
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