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N(4)-Tetradentate chelators efficiently regulate copper homeostasis and prevent ROS production induced by copper-amyloid-β(1-16), even in the presence of an excess of zinc

The disruption of copper homeostasis and the oxidative stress induced by Cu-amyloids are crucial features of Alzheimer’s disease pathology. The copper specific N(4)-tetradendate ligands TDMQ20 and 1 are able to fully inhibit in vitro the aerobic oxidation of ascorbate induced by Cu-Aβ(1-16), even in...

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Bibliografische gegevens
Gepubliceerd in:Chemistry
Hoofdauteurs: Zhang, Weixin, Liu, Yan, Hureau, Christelle, Robert, Anne, Meunier, Bernard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120676/
https://ncbi.nlm.nih.gov/pubmed/29687932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201801387
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