High-throughput single-cell DNA sequencing of acute myeloid leukemia tumors with droplet microfluidics

To enable the characterization of genetic heterogeneity in tumor cell populations, we developed a novel microfluidic approach that barcodes amplified genomic DNA from thousands of individual cancer cells confined to droplets. The barcodes are then used to reassemble the genetic profiles of cells fro...

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Publicat a:Genome Res
Autors principals: Pellegrino, Maurizio, Sciambi, Adam, Treusch, Sebastian, Durruthy-Durruthy, Robert, Gokhale, Kaustubh, Jacob, Jose, Chen, Tina X., Geis, Jennifer A., Oldham, William, Matthews, Jairo, Kantarjian, Hagop, Futreal, P. Andrew, Patel, Keyur, Jones, Keith W., Takahashi, Koichi, Eastburn, Dennis J.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2018
Matèries:
Method
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120635/
https://ncbi.nlm.nih.gov/pubmed/30087104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.232272.117
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