Nitric oxide promotes cancer cell dedifferentiation by disrupting an Oct4:caveolin-1 complex: A new regulatory mechanism for cancer stem cell formation

Cancer stem cells (CSCs) are unique populations of cells that can self-renew and generate different cancer cell lineages. Although CSCs are believed to be a promising target for novel therapies, the specific mechanisms by which these putative therapeutics could intervene are less clear. Nitric oxide...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Maiuthed, Arnatchai, Bhummaphan, Narumol, Luanpitpong, Sudjit, Mutirangura, Apiwat, Aporntewan, Chatchawit, Meeprasert, Arthitaya, Rungrotmongkol, Thanyada, Rojanasakul, Yon, Chanvorachote, Pithi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120192/
https://ncbi.nlm.nih.gov/pubmed/29986880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000287
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