Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol

BACKGROUND: Spiropyrrolidine tethered piperidone heterocyclic hybrids were synthesized with complete regio- and stereoselectively in excellent yield via a tandem three-component 1,3-dipolar cycloaddition and subsequent enamine reaction in [bmim]Br. The synthesized compounds were evaluated for their...

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Detalhes bibliográficos
Publicado no:Chem Cent J
Main Authors: Arumugam, Natarajan, Almansour, Abdulrahman I., Kumar, Raju Suresh, Al-thamili, Dhaifallah M., Periyasami, Govindasami, Periasamy, V. S., Athinarayanan, Jegan, Alshatwi, Ali A., Mahalingam, S. M., Menéndez, J. Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119554/
https://ncbi.nlm.nih.gov/pubmed/30173362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0462-x
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