Effects of methylphenidate on cognition and behaviour in children with neurofibromatosis type 1: a study protocol for a randomised placebo-controlled crossover trial

INTRODUCTION: Dopamine dysregulation has been identified as a key modulator of behavioural impairment in neurofibromatosis type 1 (NF1) and a potential therapeutic target. Preclinical research demonstrates reduced dopamine in the brains of genetically engineered NF1 mouse strains is associated with...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Pride, Natalie A, Barton, Belinda, Hutchins, Paul, Coghill, David R, Korgaonkar, Mayuresh S, Hearps, Stephen J C, Rouel, Melissa, Malarbi, Stephanie, North, Kathryn N, Payne, Jonathan M
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Pharmacology and Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119452/
https://ncbi.nlm.nih.gov/pubmed/30166301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2018-021800
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