Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

OBJECTIVES: We sought to understand why randomised controlled trials in septic shock have failed to demonstrate effectiveness in the face of improving overall outcomes for patients and seemingly promising results of early phase trials of interventions. DESIGN: We performed a retrospective analysis o...

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Detalhes bibliográficos
Publicado no:BMJ Open
Main Authors: Wong, Joshua L C, Mason, Alexina J, Gordon, Anthony C, Brett, Stephen J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Intensive Care
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119416/
https://ncbi.nlm.nih.gov/pubmed/30158216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2017-020068
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