Are large randomised controlled trials in severe sepsis and septic shock statistically disadvantaged by repeated inadvertent underestimates of required sample size?

OBJECTIVES: We sought to understand why randomised controlled trials in septic shock have failed to demonstrate effectiveness in the face of improving overall outcomes for patients and seemingly promising results of early phase trials of interventions. DESIGN: We performed a retrospective analysis o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:BMJ Open
Egile Nagusiak: Wong, Joshua L C, Mason, Alexina J, Gordon, Anthony C, Brett, Stephen J
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMJ Publishing Group 2018
Gaiak:
Intensive Care
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119416/
https://ncbi.nlm.nih.gov/pubmed/30158216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2017-020068
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