TET2 controls chemoresistant slow-cycling cancer cell survival and tumor recurrence

Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. We have adapted the pulse-chase expression of H2BeGFP for labeling and isolating slow-cycling cancer cells (SCCCs). SCCCs showed ca...

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Published in:J Clin Invest
Main Authors: Puig, Isabel, Tenbaum, Stephan P., Chicote, Irene, Arqués, Oriol, Martínez-Quintanilla, Jordi, Cuesta-Borrás, Estefania, Ramírez, Lorena, Gonzalo, Pilar, Soto, Atenea, Aguilar, Susana, Eguizabal, Cristina, Caratù, Ginevra, Prat, Aleix, Argilés, Guillem, Landolfi, Stefania, Casanovas, Oriol, Serra, Violeta, Villanueva, Alberto, Arroyo, Alicia G., Terracciano, Luigi, Nuciforo, Paolo, Seoane, Joan, Recio, Juan A., Vivancos, Ana, Dienstmann, Rodrigo, Tabernero, Josep, Palmer, Héctor G.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118637/
https://ncbi.nlm.nih.gov/pubmed/29944140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96393
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