HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection

Lysine-63–linked (K63-linked) polyubiquitination of TRAF3 coordinates the engagement of pattern-recognition receptors with recruited adaptor proteins and downstream activator TBK1 in pathways that induce type I IFN. Whether autoubiquitination or other E3 ligases mediate K63-linked TRAF3 polyubiquiti...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Li, Fubing, Li, Yang, Liang, Huichun, Xu, Tao, Kong, Yanjie, Huang, Maobo, Xiao, Ji, Chen, Xi, Xia, Houjun, Wu, Yingying, Zhou, Zhongmei, Guo, Xiaomin, Hu, Chunmiao, Yang, Chuanyu, Cheng, Xu, Chen, Ceshi, Qi, Xiaopeng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118574/
https://ncbi.nlm.nih.gov/pubmed/29920190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120406
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